Villaraza pic 2016

Dr. Aaron Joseph Lucero Villaraza

Position: Professor                                                       

Education: Ph.D. (Chemisty), University of Manchester (UK), 2008                     

Email: emailvillaraza


2008 (July) - 2010 (Aug): Radioimmune and Inorganic Section, Radiation Oncology Branch, National Cancer Institute, USA National Institutes of Health
2011 (Oct-Dec): Department of Biology and Department of Medicinal Chemistry, University of Utah
2012 (Oct) - 2013 (May): Department of Chemistry, University of Oxford


medicinal chemistry

1.) inorganic lanthanide complexes for medical diagnostics
2.) neuroactive marine-derived peptides
3.) antimalarial peptides



1.) “Synthesis and Spectroscopic Studies on Azo-Dye Derivatives of Polymetallic Lanthanide Complexes: Using Diazotization to Link Metal Complexes Together” Placidi, M.P.; Villaraza, A.J.L.; Natrajan, L.S.; Sykes, D.; Kenwright, A.M.; Faulkner, S. J. Am. Chem. Soc. 2009, 131, 9916-9917.

2.) “Controlled Preparation of a Heterometallic Lanthanide Complex Containing Different Lanthanides in Symmetrical Binding Pockets” Natrajan, L.S.; Villaraza, A.J.L.; Kenwright, A.M.; Faulkner, S. Chem. Commun. 2009, 40, 6020-6022.

3.) “Macromolecules, Dendrimers and Nanomaterials in Magnetic Resonance Imaging: The Interplay Between Size, Function and Pharmacokinetics” Villaraza, A.J.L.; Bumb, A.; Brechbiel, M.W. Chem. Rev. 2010, 110, 2921-2959.

4.) “Improved Speciation Characteristics of PEGylated Indocyanine Green-Labeled Panitumumab: Revisiting the Solution and Spectroscopic Properties of a Near-Infrared Emitting anti-HER1 Antibody for Optical Imaging of Cancer” Villaraza, A.J.L.; Milenic, D. E.; Brechbiel, M.W. Bioconjugate Chem. 2010, 21, 2305-2312.

5.) “A Bacterial Source for Mollusk Pyrone Polyketides” Lin, Z.; Torres, J.P.; Ammon, M.A.; Marret, L.; Teickert, R.W.; Reilly, C.A.; Kwan, J.C.; Tianero, M.D.; Peraud, O.; Cox, J.E.; Light, A.R.; Villaraza, A.J.L.; Haygood, M.G.; Concepcion, G.P.; Olivera, B.M.; Schmidt, E.W. Chem. Biol. 2013, 20, 73-81.

6.) “Ion Charge Density Governs Selectivity in the Formation of Metal-Xylenol Orange (M-XO) Complexes” Belleza, O.V.; Villaraza, A.J.L. Inorg. Chem. Commun. 2014, 47, 87-92.

7.) “Synthesis and Bioactivity of Nobilamide B” Jacinto, M.P.V.; Flores, M.S.; Lin, Z.; Concepcion, G.P.; Schmidt, E.W.; Faulkner, S.; Villaraza, A.J.L. RSC Adv. 2014, 4, 37609-37612.

8.) “Gd-XO: a colourimetric probe for the complexation of Gd3+ with DO3A-type ligands” Suazo, K.F.G.; Villaraza, A.J.L. Anal. Methods 2015, 7, 8967-8969.

9.) "Relative Ligand Exchange Rates in Gd-based MRI Contrast Agent Formation as Probed by Gd-XO Complex", Belleza, O.J.V.; Naraga, A.M.B. and Villaraza, A.J.L. J. Chin. Chem. Soc. 2018, 65, 561-566.

10.) "On the Inhibition of Capsaicin Response in Dorsal Root Ganglion Neurons by Nobilamide B and Analogues: A Structure-Activity Relationship Study" Belleza, O.J.V.; Tun, J.O.; Concepcion, G.P.; Villaraza, A.J.L. Med. Chem. Commun. 2018, 9, 1673-1678.

11.)  "Total Synthesis of μ-conotoxin lt5d" Naraga, A.M.B.; Belleza, O.J.V.; Villaraza, A.J.L. RSC Adv. 2018, 8, 36579-36583.

12.) "Effect of Solvent on Gd(DOTA)‒ Complex Formation: A Preliminary Investigation" Pineda, E.G.S. and Villaraza, A.J.L. Phil. J. Sci., 2019, 148, 167-172.